Mitochondria and Cell Death by David M. Hockenbery

Mitochondria and Cell Death



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Mitochondria and Cell Death David M. Hockenbery ebook
ISBN: 9781493936106
Page: 286
Format: pdf
Publisher: Springer New York


Once released into the cytosol, these mitochondrial proteins activate both caspase-dependent and -independent cell death pathways. Mitochondrial regulation of apoptotic celldeath. Department of Immunology, St Jude Children's Research Hospital,. Programmed cell death is a fundamental requirement for embryogenesis, organ metamorphosis and tissue homeostasis. Apoptotic proteins that target mitochondria affect them in different ways. Nitric oxide, mitochondria, and celldeath. The intrinsic pathway, mitochondrial outer membrane per- meabilization activation of the caspase proteases that cause apoptotic cell death. Although required for life, paradoxically, mitochondria are often essential for initiating apoptotic cell death. Viral proteins targeting mitochondria: controlling cell death. Mitochondrial Ca2+ uptake in combination with NO production triggers the collapse of mitochondrial membrane potential, culminating in delayed cell death. Both pathways induce cell death by activating caspases, which are proteases, . Doi: 10.1007/s10495-009-0363-5.Mitochondria mediated cell death in diabetes. Mechanistic aspects and methodological issues. Mitochondria play an important role in regulating the life and death of cells. Mitochondria play a central role in both apoptosis and necrosis through the opening of the mitochondrial permeability transition pore (MPTP). Calcium and mitochondria in the regulation of cell death.





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